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Introduction

Rosuvastatin (Crestor) is widely used in the management of various lipid disorders. The therapeutic profile of rosuvastatin includes effects on multiple organs and pathways, including the cardiovascular system, the gastrointestinal system, the nervous system, the central nervous system, the lungs, and the skin. Rosuvastatin is a selective and potent inhibitor of matrix metalloproteinases (MMPs) and has been shown to reduce elevated LDL cholesterol concentrations, reduce the progression of atherosclerosis, and reduce the risk of cardiovascular events. As a result, it is a potential first-line medication for patients with hypercholesterolemia, and rosuvastatin is increasingly being prescribed as a second-line therapy for patients with primary hypercholesterolemia. Herein, we evaluated the safety and tolerability of rosuvastatin in a multicenter, randomized, double-blind, placebo-controlled, placebo-controlled, study in adult patients with primary hypercholesterolemia.

Methods

This randomized, double-blind, placebo-controlled, multicenter, parallel-group study was conducted at the Clinical Center in University of North Carolina, Chapel Hill, NC, from January 1, 2010, to December 30, 2012. Patients with primary hypercholesterolemia with at least 2 mm of Hg (or at least 2% of total cholesterol) and a total cholesterol ≥= 50 mmol/L (the “normal range”) were included. Randomization was performed according to a computer-generated random number. At the end of the study, patients with primary hypercholesterolemia with a total cholesterol >50 mmol/L (or at least 2% of total cholesterol) were randomized to receive placebo (n = 6; rosuvastatin 5 mg) or rosuvastatin (n = 9) at a dose of 50 mg daily for 12 weeks. Patients were randomized to receive placebo or rosuvastatin 5 mg daily for a total of 10 weeks.

Results

During the study period, 646 patients (mean age, 35.4 years; 63% men; 73% were white; 55% were Asian) were randomized to receive placebo or rosuvastatin at a dose of 5 mg daily for 12 weeks. Overall, 86% (n = 546) of the patients had a baseline LDL cholesterol ≥ 30 mg/dL (or at least 2% of total cholesterol) and LDL cholesterol >50 mg/dL (or at least 2% of total cholesterol) at baseline.

Patients were randomized to receive rosuvastatin (n = 6) or placebo (n = 9) at a dose of 5 mg daily for 12 weeks. Patients were not able to achieve target LDL cholesterol levels (e.g., LDL cholesterol >50 mg/dL) at any of the time points (week 1, week 2, and week 3) during treatment. The mean LDL cholesterol >50 mg/dL at baseline was 2.9 mmol/L (SD, 1.6) in the rosuvastatin group compared with 3.5 mmol/L (SD, 1.6) in the placebo group at the 12-week visit (p = 0.003). The mean LDL cholesterol >30 mg/dL and the mean LDL cholesterol >50 mg/dL at the 12-week visit were <2% and ≥2%, respectively, in the rosuvastatin group compared with >2% and ≥2% in the placebo group at the 12-week visit (p = 0.001).

Patients in the rosuvastatin group reported a median increase in LDL cholesterol (<50 mg/dL) at week 12 compared with baseline.

The median LDL cholesterol >30 mg/dL and the mean LDL cholesterol >50 mg/dL at the 12-week visit were <1% and >1% in the rosuvastatin group compared with >1% and >1% in the placebo group at the 12-week visit (p = 0.005).

A total of 764 patients (mean age, 39.9 years; 57% men; 66% were white; 61% were Asian) at the 12-week visit had a baseline LDL cholesterol >30 mg/dL at baseline.

Hi there, my wife and I are having a good time. We are both very happy with our lives, but her husband recently started taking Crestor (rosuvastatin) and she was really worried about how it affected her life. It's not as bad as I thought. Now that we have been married for almost 20 years, we haven't had any major heart problems, and we are now having more difficulty sleeping and not getting enough exercise. We've been told by our doctors that we have too many cholesterol numbers to have any effect on our weight, so we have been taking Crestor for 10 years, and it's not as effective as Crestor. I also don't like to have to worry about weight when we exercise, and we're also not getting enough sleep. I would highly recommend taking this medicine if you are already on it. It's also cheaper than what I have, so it's not a bad choice. It can help you manage your cholesterol levels, but it can also be a good option for people who have no other treatment options. It also has a long term effect, so it's important to speak to your doctor about it.

Hi there, we've been on Crestor (rosuvastatin) for 10 years and have been losing weight. It's been our biggest challenge, but we feel much more confident now, because we can easily keep going back and we are having more problems getting to the gym and doing the right thing. We have also tried a very small dose of Zocor (simvastatin) but it has only worked for 20 years.Good day, my wife and I. I'm so sorry to hear about the loss of so much weight. We are both in recovery and feeling really better now. I'll definitely be taking this medicine. Thanks so much.Hi there, my wife and I are having a really good time. We're both very happy with our lives, but our health isn't good. I was recently diagnosed with a liver disease and it's been so bad that I can't eat or sleep. I'm still a little nervous about going to the gym and not getting enough exercise, and I'm not able to lose enough weight. I've tried a little exercise program and I have to use the right amount of cardio because I'm afraid that my liver will cause me to lose so much weight. I'm not sure what else I should do, but I'm afraid I might end up going through more damage. Thanks for your help.I have been taking Crestor for 10 years and haven't had any side effects, but it's definitely not going to be as bad as I thought. My liver is very bad, and I'm afraid it might cause me to lose weight. I'm also worried that the cholesterol levels may be increasing, so I'm thinking that the side effects will be the same. I'll definitely start taking this medicine if needed. I'm a bit nervous about going to the gym, but it's just not working. I'm just scared.

Hi, we've been on Crestor (rosuvastatin) for 10 years and have been losing weight.

Introduction About CRESTOR 5 TABLET

CRESTOR 5 TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.

By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 5 TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.

Before taking CRESTOR 5 TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 5 TABLET if you are pregnant or breastfeeding without consulting your doctor.

CRESTOR 5 TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 5 TABLET as a precaution.

The most common side effects of taking CRESTOR 5 TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 5 TABLET.

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This medicine can cause side effects, such as headache, nausea, fatigue, muscle pain, constipation, liver problems, bone pain, and skin rashes. If you get any of these side effects, stop taking CRESTOR 5 TABLET and contact your doctor immediately.

Introduction About CRESTOR 10MG TABLET

CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.

By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.

Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.

CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.

The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.

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CRESTOR 10MG TABLET is a safe and effective treatment for high cholesterol levels. It reduces blood sugar levels and helps you to manage cholesterol levels more effectively. Additionally, it lowers the risk of developing diabetes by lowering blood sugar levels, which may reduce the need for medication and increase the risk of complications such as strokes, heart attacks and myopathy.

Before taking CRESTOR 10MG TABLET inform your doctor if you have kidney, liver or heart problems. You must also inform your doctor if you are suffering from congestive heart failure, liver or heart failure, history of or related conditions like chronic heart disease, stroke or liver disease.

CRESTOR 10MG TABLET may increase your nerve damage, so it is important to inform your doctor if you have suffered from any form of peripheral neuropathy or neuromedia in your limbs or how you look after yourself.

It is crucial to follow your doctor's instructions and not to consume grapefruit juice or grapefruit products with this medicine as it may cause side effects like drowsiness, nausea, dry mouth, increased blood pressure, constipation, insomnia, rapid heart rate, hair loss and blurred vision.

Taking CRESTOR 10MG TABLET with a high-fat meal may reduce the effectiveness of the medicine. It also thwarts the absorption of CRESTOR 10MG TABLET in the intestine, so it can be taken only when the patient is overweight or obese.

High blood sugar levels may cause serious complications such as multiple myeloma, leukemia, deep vein thrombosis, pulmonary embolism and rhabdomyolysis. It is important to inform your doctor about all the co-pays or deductibles you may be receiving with this medicine, as well as any other medications or supplements you are taking.

It is important to mention that CRESTOR 10MG TABLET may rarely cause a severe liver condition, so inform your doctor if you are on hemodialysis or if you have any liver patients to avoid this. You must also mention any pre-existing liver disease or kidney problems to your doctor so that they can decide if CRESTOR 10MG TABLET is right for you.

Inform your doctor if you have any lung, liver or heart problems. You must also have a thorough skin and abdominal examination before taking CRESTOR 10MG TABLET to ensure that it is safe for you to use.

You must also mention any history of heart attack, irregular heartbeats, blood clots, stroke, heart failure, liver problems, stomach ulcer or bleeding and kidney or liver problems to your doctor so that they can decide if CRESTOR 10MG TABLET is suitable for you.

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